![]() ![]() ![]() We consider major congenital infections that access the placenta from hematogenous or decidual route. Here, we outline the anatomy of the human placenta and uterine lining, the decidua, and discuss the potential capacity of pathogen pattern recognition and other host defense strategies present in the innate immune cells at the placental-decidual interface. Innate immune responses, orchestrated by maternal and fetal cells at the decidual-placental interface, are the first line of defense to avoid vertical transmission. Infectious agents can potentially breach the placental barrier resulting in pathogenic transmission from mother to fetus. ![]() 3Department of Obstetrics and Gynecology, School of Medicine, Makerere University, Kampala, Ugandaĭuring pregnancy, the placenta forms the anatomical barrier between the mother and developing fetus.2Centre for Trophoblast Research, University of Cambridge, Cambridge, United Kingdom.1Wellcome Sanger Institute, Cambridge, United Kingdom.Regina Hoo 1,2, Annettee Nakimuli 1,3 and Roser Vento-Tormo 1,2 * ![]()
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